Combinational exposure to Bisphenol A and a high-fat diet causes trans-generational Malfunction of the female reproductive system in mice

Rongfeng Huang; Jiayu Li; Maolin Liao; Li Ma; Irakoze Laurent; Xiaojing Lin; Yunqi Zhang; Rufei Gao; Yubin Ding; Xiaoqiu Xiao

doi:10.1016/j.mce.2021.111507

Combinational exposure to Bisphenol A and a high-fat diet causes trans-generational Malfunction of the female reproductive system in mice

Mol Cell Endocrinol. 2022 Feb 5:541:111507. doi: 10.1016/j.mce.2021.111507. Epub 2021 Nov 13.

Authors

Affiliations

¹ Department of Obstetrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China; State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
² State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³ Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China.
⁴ Department of Obstetrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China; State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: xiaoxiaoqiu@hospital.cqmu.edu.cn.

PMID: 34785282
DOI: 10.1016/j.mce.2021.111507

Abstract

Bisphenol A (BPA) is a common endocrine disruptor and a high-fat diet (HFD) also affects fertility. However, little is known about the long-term consequences of simultaneous exposure to BPA and a HFD on reproductive health. Herein, we assessed the effects of maternal exposure to BPA in combination with a HFD on reproductive function in subsequent generations of female mice and evaluated its effects on the hypothalamic-pituitary-gonadal axis. We found that the combination of maternal exposure to BPA and a HFD led to increased urine BPA levels, precocious puberty, altered estrous cyclicity, decreased follicle numbers, and altered hypothalamic Kiss1 methylation status in F1 and F2 mice. Therefore, we demonstrated that maternal exposure to BPA in combination with a HFD exerts a trans-generational effect on female reproduction.

Keywords: Bisphenol A; Endocrine disrupter; Female reproductive system; High-fat diet; Trans-generational effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzhydryl Compounds / toxicity*
Diet, High-Fat / adverse effects*
Dietary Fats / adverse effects
Endocrine Disruptors / toxicity
Estrous Cycle / drug effects
Estrous Cycle / physiology
Female
Genitalia, Female / drug effects
Genitalia, Female / physiopathology*
Infertility, Female / etiology*
Male
Maternal Exposure / adverse effects
Mice
Mice, Inbred ICR
Phenols / toxicity*
Pregnancy
Prenatal Exposure Delayed Effects / etiology
Prenatal Exposure Delayed Effects / physiopathology*
Reproduction / drug effects
Reproduction / physiology
Sexual Maturation / drug effects
Sexual Maturation / physiology

Substances

Benzhydryl Compounds
Dietary Fats
Endocrine Disruptors
Phenols
bisphenol A