In the studies of chiral organic stereochemistry, it is important to use enantiopure compounds. For this purpose, the chiral HPLC (High-Pressure Liquid Chromatography) columns containing chiral stationary phases were invented by Y. Okamoto and coworkers for enantio-separating various racemic compounds. In addition, the use of chiral auxiliaries is also useful for preparing enantiopure compounds and also for determining their absolute configurations, where covalent-bonded diastereomers are separated by HPLC on silica gel. In this review article, these HPLC methods will be discussed together with the applications to some interesting organic compounds including light-powered chiral molecular motors.
Keywords: (+)-poly(triphenylmethyl methacrylate); (R)-(−)-2-methoxy-2-(1-naphthyl)propionic acid (MαNP acid); (−)-camphor-sultam dichlorophthalic acid (CSDP acid); 1H NMR diamagnetic anisotropy method; CD exciton chirality method; cellulose tris(3,5-dimethylphenylcarbamate); π-Electron SCF-CI-DV MO method.
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