GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Constantinos Demetriades; Julian Nüchel; Markus Plomann

doi:10.15698/cst2021.11.259

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Cell Stress. 2021 Oct 15;5(11):173-175. doi: 10.15698/cst2021.11.259. eCollection 2021 Nov.

Authors

Constantinos Demetriades^{1

2}, Julian Nüchel¹, Markus Plomann³

Affiliations

¹ Max Planck Institute for Biology of Ageing (MPI-AGE), 50931 Cologne, Germany.
² University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
³ University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Biochemistry, 50931 Cologne, Germany.

Abstract

Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity of signaling pathways, and interact with their environment by qualitatively and quantitatively modifying their intracellular, surface, and extracellular proteomes. How this delicate communication takes place is a hot topic in cell biological research, and has important implications for human disease.

Keywords: GRASP55; Golgi; Tuberous Sclerosis Complex (TSC); cellular stress response; mTORC1; rapamycin; unconventional protein secretion (UPS).

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