SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Daniel Perez-Zsolt; Jordana Muñoz-Basagoiti; Jordi Rodon; Marc Elosua-Bayes; Dàlia Raïch-Regué; Cristina Risco; Martin Sachse; Maria Pino; Sanjeev Gumber; Mirko Paiardini; Jakub Chojnacki; Itziar Erkizia; Xabier Muñiz-Trabudua; Ester Ballana; Eva Riveira-Muñoz; Marc Noguera-Julian; Roger Paredes; Benjamin Trinité; Ferran Tarrés-Freixas; Ignacio Blanco; Victor Guallar; Jorge Carrillo; Julià Blanco; Amalio Telenti; Holger Heyn; Joaquim Segalés; Bonaventura Clotet; Javier Martinez-Picado; Júlia Vergara-Alert; Nuria Izquierdo-Useros

doi:10.1038/s41423-021-00794-6

SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Cell Mol Immunol. 2021 Dec;18(12):2676-2678. doi: 10.1038/s41423-021-00794-6. Epub 2021 Nov 15.

Authors

Daniel Perez-Zsolt^#¹, Jordana Muñoz-Basagoiti^#¹, Jordi Rodon^#², Marc Elosua-Bayes^#³, Dàlia Raïch-Regué¹, Cristina Risco⁴, Martin Sachse⁴, Maria Pino⁵, Sanjeev Gumber^{6

7}, Mirko Paiardini^{5

6}, Jakub Chojnacki¹, Itziar Erkizia¹, Xabier Muñiz-Trabudua¹, Ester Ballana^{1

8}, Eva Riveira-Muñoz¹, Marc Noguera-Julian^{1

9}, Roger Paredes¹, Benjamin Trinité¹, Ferran Tarrés-Freixas¹, Ignacio Blanco⁸, Victor Guallar^{10

11}, Jorge Carrillo¹, Julià Blanco^{1

8

9}, Amalio Telenti¹², Holger Heyn^{3

13}, Joaquim Segalés^{14

15}, Bonaventura Clotet^{1

8

9}, Javier Martinez-Picado^{16

17

18

19}, Júlia Vergara-Alert²⁰, Nuria Izquierdo-Useros^{21

22}

Affiliations

¹ IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain.
² IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193, Bellaterra (Cerdanyola del Vallès), Spain.
³ CNAG-CRG, Centre for Genomic Regulation (CRG, Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
⁴ Centro Nacional de Biotecnología, CSIC, 28049, Madrid, Spain.
⁵ Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
⁶ Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.
⁷ Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
⁸ Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916, Badalona, Spain.
⁹ University of Vic-Central University of Catalonia (UVic-UCC), Vic, 08500, Spain.
¹⁰ Barcelona Supercomputing Center (BSC), 08034, Barcelona, Spain.
¹¹ Catalan Institution for Research and Advanced Studies (ICREA), 08010, Barcelona, Spain.
¹² Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, 92037, USA.
¹³ Universitat Pompeu Fabra (UPF), Barcelona, Spain.
¹⁴ UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193, Bellaterra (Cerdanyola del Vallès), Spain.
¹⁵ Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193, Bellaterra (Cerdanyola del Vallès), Spain.
¹⁶ IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain. jmpicado@irsicaixa.es.
¹⁷ Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916, Badalona, Spain. jmpicado@irsicaixa.es.
¹⁸ Catalan Institution for Research and Advanced Studies (ICREA), 08010, Barcelona, Spain. jmpicado@irsicaixa.es.
¹⁹ University of Vic-Central University of Catalonia (UVic-UCC), Vic, 08500, Spain. jmpicado@irsicaixa.es.
²⁰ IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193, Bellaterra (Cerdanyola del Vallès), Spain. julia.vergara@irta.cat.
²¹ IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain. nizquierdo@irsicaixa.es.
²² Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916, Badalona, Spain. nizquierdo@irsicaixa.es.

^# Contributed equally.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigen-Presenting Cells / metabolism
Antigen-Presenting Cells / virology
Cell Line
Dendritic Cells / metabolism*
Dendritic Cells / virology*
Humans
N-Acetylneuraminic Acid / metabolism
Receptors, Coronavirus / metabolism
SARS-CoV-2 / metabolism*
Sialic Acid Binding Ig-like Lectin 1 / metabolism*

Substances

Receptors, Coronavirus
Sialic Acid Binding Ig-like Lectin 1
N-Acetylneuraminic Acid

Grants and funding

P51 OD011132/OD/NIH HHS/United States