Cluster headache: a single tertiary center study

Neurol Res. 2022 Apr;44(4):342-352. doi: 10.1080/01616412.2021.1992101. Epub 2021 Nov 15.

Abstract

Object: The characteristics of cluster headache (CH) patients in many countries and the diagnostic and therapeutic approach have been described in several publications, but so far no clinical data have been published from Turkey.

Material methods: This is a cross-sectional retrospective study that includes all patients who were diagnosed with CH and referred to our headache clinic, Dokuz Eylül University Faculty of Medicine, Neurology Department from 1991 to January 2018.

Results: We included 114 patients (24 females and 90 males) in our study. The mean age at onset was 31.68 ± 12.72 (range 13-68). Eighty-six (78.18%) patients had episodic cluster headache (ECH) and 24 (21.82%) patients had chronic cluster headache (CCH). The age at onset was significantly higher in the patients with CCH than with ECH (p = 0.002). The most common location was orbitotemporal for both genders. The most common accompanying symptoms were lacrimation (80.73%). The male:female ratio in all patients was 3:7, 3.8:1 in those with CCH and 4:1 in those with ECH. Eighty-nine (87.25%) patients had prophylactic treatment and 60 of them received verapamil.

Conclusion: In our study, some clinical features of our patients were similar to those of Europe and America or the Asian countries and some of them not. There are regional differences in cluster headache patients. With more awareness of cluster headache and research from many countries, clinical differences can be revealed more objectively in the future.

Keywords: Headache; autonomic symptoms; clinic; cluster headache; diagnosis; trigeminal autonomic cephalgia.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Autonomic Nervous System / physiopathology
  • Chronic Disease
  • Cluster Headache / epidemiology*
  • Cluster Headache / physiopathology*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tertiary Care Centers
  • Turkey / epidemiology
  • Young Adult