Elastin in healthy and diseased lung

Howard J Vindin; Brian Gg Oliver; Anthony S Weiss

doi:10.1016/j.copbio.2021.10.025

Elastin in healthy and diseased lung

Curr Opin Biotechnol. 2022 Apr:74:15-20. doi: 10.1016/j.copbio.2021.10.025. Epub 2021 Nov 12.

Authors

Howard J Vindin¹, Brian Gg Oliver², Anthony S Weiss³

Affiliations

¹ Charles Perkins Centre, The University of Sydney, Sydney 2006, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, 2006 Sydney, NSW, Australia; The Woolcock Institute, The University of Sydney, Sydney 2006, NSW, Australia.
² The Woolcock Institute, The University of Sydney, Sydney 2006, NSW, Australia.
³ Charles Perkins Centre, The University of Sydney, Sydney 2006, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, 2006 Sydney, NSW, Australia; Sydney Nano Institute, The University of Sydney, 2006 Sydney, NSW, Australia. Electronic address: tony.weiss@sydney.edu.au.

PMID: 34781101
DOI: 10.1016/j.copbio.2021.10.025

Abstract

Elastic fibers are an essential part of the pulmonary extracellular matrix (ECM). Intact elastin is required for normal function and its damage contributes profoundly to the etiology and pathology of lung disease. This highlights the need for novel lung-specific imaging methodology that enables high-resolution 3D visualization of the ECM. We consider elastin's involvement in chronic respiratory disease and examine recent methods for imaging and modeling of the lung in the context of advances in lung tissue engineering for research and clinical application.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Elastin*
Extracellular Matrix*
Lung / diagnostic imaging
Tissue Engineering

Substances

Elastin