Prospective assessment of psychopathological symptoms and their relation to demographic factors in primary caregivers of cancer patients throughout chemotherapy

Support Care Cancer. 2022 Mar;30(3):2467-2475. doi: 10.1007/s00520-021-06662-3. Epub 2021 Nov 15.

Abstract

Purpose: The present study aims to investigate the course of psychological symptoms through chemotherapy in a sample of primary caregivers of patients with cancer and to examine all possible correlations between psychological distress and demographic characteristics.

Methods: In this prospective study, 112 primary family caregivers of cancer patients were evaluated. Symptom checklist 90 revised (SCL-90-R) was administered to assess their pathological symptoms, the Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety. There was an evaluation at the beginning of chemotherapy and a second at the end of the patients' intravenous chemotherapy treatment (EOT).

Results: A total of 112 primary caregivers were initially enrolled in the study, and 99 (88.4%) completed it. Caregivers' psychopathology was low to moderate at both points of time (baseline and EOT). However, a considerable decrease in the Global Severity Index (GSI) emerged over time.

Conclusions: At EOT, participants reported statistically significant decreases in five aspects of SCL 90, namely Depression, phobic anxiety, obsessive-compulsive symptoms, somatization, and psychoticism. A notable finding was that female caregivers were significantly more distressed, especially when providing care to a male recipient.

Keywords: Cancer; Caregivers; Demographic factors; Prospective.

MeSH terms

  • Anxiety / epidemiology
  • Anxiety / etiology
  • Caregivers
  • Demography
  • Depression / epidemiology
  • Depression / etiology
  • Female
  • Humans
  • Male
  • Mental Disorders*
  • Neoplasms* / drug therapy
  • Prospective Studies
  • Stress, Psychological / epidemiology