The Regulatory Role of RNA Metabolism Regulator TDP-43 in Human Cancer

Xueyou Ma; Yufan Ying; Haiyun Xie; Xiaoyan Liu; Xiao Wang; Jiangfeng Li

doi:10.3389/fonc.2021.755096

The Regulatory Role of RNA Metabolism Regulator TDP-43 in Human Cancer

Front Oncol. 2021 Oct 28:11:755096. doi: 10.3389/fonc.2021.755096. eCollection 2021.

Authors

Xueyou Ma^{1

2}, Yufan Ying^{1

2}, Haiyun Xie^{1

2}, Xiaoyan Liu³, Xiao Wang^{1

2}, Jiangfeng Li^{1

2}

Affiliations

¹ Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Cancer Center, Zhejiang University, Hangzhou, China.
³ Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Abstract

TAR-DNA-binding protein-43 (TDP-43) is a member of hnRNP family and acts as both RNA and DNA binding regulator, mediating RNA metabolism and transcription regulation in various diseases. Currently, emerging evidence gradually elucidates the crucial role of TDP-43 in human cancers like it is previously widely researched in neurodegeneration diseases. A series of RNA metabolism events, including mRNA alternative splicing, transport, stability, miRNA processing, and ncRNA regulation, are all confirmed to be closely involved in various carcinogenesis and tumor progressions, which are all partially regulated and interacted by TDP-43. Herein we conducted the first overall review about TDP-43 and cancers to systematically summarize the function and precise mechanism of TDP-43 in different human cancers. We hope it would provide basic knowledge and concepts for tumor target therapy and biomarker diagnosis in the future.

Keywords: TDP-43; cancers; epigenetics; mRNA metabolism; ncRNA.

Publication types

Review