CB2 and toll-like receptors crosstalk in microglia

Antonio Carlos Pinheiro de Oliveira; Fabricio A Moreira; Bernd L Fiebich

doi:10.1016/j.tins.2021.10.012

CB₂ and toll-like receptors crosstalk in microglia

Trends Neurosci. 2022 Jan;45(1):1-2. doi: 10.1016/j.tins.2021.10.012. Epub 2021 Nov 11.

Authors

Antonio Carlos Pinheiro de Oliveira¹, Fabricio A Moreira², Bernd L Fiebich²

Affiliations

¹ Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: antoniooliveira@icb.ufmg.br.
² Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

PMID: 34776238
DOI: 10.1016/j.tins.2021.10.012

Abstract

Microglia play a major role in certain neuropathological conditions. In a recent paper, Reusch et al. demonstrated how signaling pathways downstream of cannabinoid type 2 (CB₂) and toll-like receptors (TLRs) converge in these cells. The findings suggest that CB₂ receptors play a permissive role in microglia activation mediated by TLRs.

Keywords: cannabinoid; cell signaling; glia; immune system; neuroinflammation; p38 MAPK.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Microglia* / metabolism
Signal Transduction / physiology
Toll-Like Receptors* / metabolism

Substances

Toll-Like Receptors