AiED: Artificial intelligence for the detection of intracranial interictal epileptiform discharges

Abstract

Objective: Deep learning provides an appealing solution for the ongoing challenge of automatically classifying intracranial interictal epileptiform discharges (IEDs). We report results from an automated method consisting of a template-matching algorithm and convolutional neural network (CNN) for the detection of intracranial IEDs ("AiED").

Methods: 1000 intracranial electroencephalogram (EEG) epochs extracted randomly from 307 subjects with refractory epilepsy were annotated independently by two expert neurophysiologists. These annotated epochs were divided into 1062 two-second epochs with IEDs and 1428 two-second epochs without IEDs, which were transformed into spectrograms prior to training the neural network. The highest performing network was validated on an annotated external test set.

Results: The final network had an F1-score of 0.95 (95% CI: 0.91-0.98) and an average Area Under the Receiver Operating Characteristic of 0.98 (95% CI: 0.96-1.00). For the external test set, it showed an overall F1-score of 0.71, correctly identifying 100% of all high-amplitude IED complexes, 96.23% of all high-amplitude isolated IEDs, and 66.15% of all IEDs of atypical morphology.

Conclusions: Template-matching combined with a CNN offers a fast, robust method for detecting intracranial IEDs.

Significance: "AiED" is generalizable and achieves comparable performance to human reviewers; it may support clinical and research EEG analyses.

Keywords: Artificial intelligence; CNN; Deep learning; EEG; Epilepsy; IED detection; Interictal epileptiform discharges.