Obstetrics and gynecology in Ehlers-Danlos syndrome: A brief review and update

Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):593-598. doi: 10.1002/ajmg.c.31945. Epub 2021 Nov 12.

Abstract

The Ehlers-Danlos syndromes (EDSs) are a group of hereditary disorders affecting collagen and connective tissue. Gynecologic and obstetric complications occur with increased frequency and severity due to these abnormalities. Recent studies suggest that some complications, including endometriosis and premature rupture of the membranes may occur less often than previously thought. In addition, having a known diagnosis allows anticipatory planning, resulting in lower morbidity from hemorrhage and tissue injury. With continued progress in understanding the underlying mechanisms of EDS, more effective treatments can be developed.

Keywords: Ehlers-Danlos syndrome; dysmenorrhea; hemorrhage; preterm delivery.

Publication types

  • Review

MeSH terms

  • Collagen
  • Ehlers-Danlos Syndrome*
  • Female
  • Gynecology*
  • Humans
  • Obstetrics*
  • Pregnancy

Substances

  • Collagen