A Journey from June 2018 to October 2021 with N, N-Dimethylformamide and N, N-Dimethylacetamide as Reactants

Jacques Muzart

doi:10.3390/molecules26216374

A Journey from June 2018 to October 2021 with N, N-Dimethylformamide and N, N-Dimethylacetamide as Reactants

Molecules. 2021 Oct 21;26(21):6374. doi: 10.3390/molecules26216374.

Author

Jacques Muzart¹

Affiliation

¹ Institut de Chimie Moléculaire de Reims, CNRS-Université de Reims Champagne-Ardenne, B.P. 1039, CEDEX 2, 51687 Reims, France.

Abstract

A rich array of reactions occur using N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAc) as reactants, these two amides being able to deliver their own H, C, N, and O atoms for the synthesis of a variety of compounds. This account highlights the literature published since June 2018, completing previous reviews by the author.

Keywords: DMAc; DMF; N,N-dimethylacetamide; N,N-dimethylformamide; amidation; amination; cyanation; cyclization; formylation; insertion.

Publication types

Review