Deciphering Evolutionary Dynamics and Lineage Plasticity in Aggressive Prostate Cancer

Natasha Kyprianou; Fabrice Lucien

doi:10.3390/ijms222111645

Deciphering Evolutionary Dynamics and Lineage Plasticity in Aggressive Prostate Cancer

Int J Mol Sci. 2021 Oct 28;22(21):11645. doi: 10.3390/ijms222111645.

Authors

Natasha Kyprianou¹, Fabrice Lucien²

Affiliations

¹ Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² Department of Urology, Mayo Clinic, Rochester, MN 55902, USA.

Abstract

This Special Issue focuses on the molecular mechanisms involved in therapeutic resistance, lineage plasticity, and phenotypic reprogramming leading to prostate cancer recurrence and, ultimately, lethal disease [...].

Publication types

Editorial
Introductory Journal Article

MeSH terms

Androgen Receptor Antagonists / therapeutic use
Androgens / metabolism
Drug Resistance, Neoplasm
Humans
Male
Neoplasm Recurrence, Local / metabolism
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / therapy
Prostate / drug effects
Prostate / metabolism
Prostate / pathology*
Prostatic Neoplasms / metabolism
Prostatic Neoplasms / pathology*
Prostatic Neoplasms / therapy
Receptors, Androgen / analysis
Receptors, Androgen / metabolism
Signal Transduction / drug effects

Substances

Androgen Receptor Antagonists
Androgens
Receptors, Androgen