Do they come together? Protein quality control, stress-activated signaling, and "sarcostat" in hypertrophic cardiomyopathy progression

Roua Hassoun; Heidi Budde; Saltanat Zhazykbayeva; Melissa Herwig; Marcel Sieme; Simin Delalat; Nusratul Mostafi; Kamilla Gömöri; Melina Tangos; Muhammad Jarkas; Steffen Pabel; Stefanie Bruckmüller; Marina Skrygan; Mária Lódi; Kornelia Jaquet; Vasco Sequeira; Thilo Gambichler; Cris Dos Remedios; Árpád Kovács; Hans Georg Mannherz; Andreas Mügge; Samuel Sossalla; Nazha Hamdani

doi:10.1016/j.ijcard.2021.11.002

Do they come together? Protein quality control, stress-activated signaling, and "sarcostat" in hypertrophic cardiomyopathy progression

Int J Cardiol. 2022 Jan 15:347:44-45. doi: 10.1016/j.ijcard.2021.11.002. Epub 2021 Nov 10.

Authors

Roua Hassoun¹, Heidi Budde², Saltanat Zhazykbayeva³, Melissa Herwig⁴, Marcel Sieme⁵, Simin Delalat⁶, Nusratul Mostafi⁷, Kamilla Gömöri⁸, Melina Tangos⁸, Muhammad Jarkas⁸, Steffen Pabel⁹, Stefanie Bruckmüller¹⁰, Marina Skrygan¹¹, Mária Lódi¹², Kornelia Jaquet¹³, Vasco Sequeira¹⁴, Thilo Gambichler¹⁵, Cris Dos Remedios¹⁶, Árpád Kovács¹⁷, Hans Georg Mannherz¹⁸, Andreas Mügge¹⁹, Samuel Sossalla²⁰, Nazha Hamdani²¹

Affiliations

¹ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Roua.Hassoun@ruhr-uni-bochum.de.
² Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Heidi.Budde@ruhr-uni-bochum.de.
³ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Saltanat.Zhazykbayeva@ruhr-uni-bochum.de.
⁴ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: melissa.herwig@rub.de.
⁵ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Marcel.Sieme@ruhr-uni-bochum.de.
⁶ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Simin.Delalat@ruhr-uni-bochum.de.
⁷ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Nusratul.Mostafi@rub.de.
⁸ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany.
⁹ Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany. Electronic address: Steffen.Pabel@klinik.uni-regensburg.de.
¹⁰ Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, Bochum, Germany. Electronic address: stefanie.bruckmueller@klinikum-bochum.de.
¹¹ Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, Bochum, Germany. Electronic address: m.skrygan@klinikum-bochum.de.
¹² Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany. Electronic address: maria.lodi@rub.de.
¹³ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: kornelia.jaquet@rub.de.
¹⁴ Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Germany. Electronic address: Sequeira_V@ukw.de.
¹⁵ Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, Bochum, Germany. Electronic address: thilo.gambichler@klinikum-bochum.de.
¹⁶ Molecular Biophysics, Faculty of Medicine and Health, Victor Chang Cardiac Research Institute, Darlinghurst, Australia. Electronic address: crisdos@anatomy.usyd.edu.au.
¹⁷ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: kovacs.arpad@med.unideb.hu.
¹⁸ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Anatomy and Molecular Embryology, Ruhr University Bochum, Bochum, Germany. Electronic address: hans.g.mannherz@rub.de.
¹⁹ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Andreas.Muegge@ruhr-uni-bochum.de.
²⁰ Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany; Clinic for Cardiology & Pneumology, Georg-August University Goettingen, and DZHK (German Centre for Cardiovascular Research), partner site Goettingen, Germany. Electronic address: samuel.sossalla@klinik.uni-regensburg.de.
²¹ Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: nazha.hamdani@rub.de.

PMID: 34767897
DOI: 10.1016/j.ijcard.2021.11.002

No abstract available

Keywords: Hypertrophic cardiomyopathy; Protein quality control; Sarcostat; Stress-activated signaling.

Publication types

Letter

MeSH terms

Cardiomyopathy, Hypertrophic* / diagnosis
Humans
Proteins

Substances

Proteins