Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

Jipeng Jiang; Jie Mei; Shaoqiong Yi; Changjiang Feng; Yongfu Ma; Yang Liu; Ying Liu; Chunying Chen

doi:10.1016/j.addr.2021.114046

Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

Adv Drug Deliv Rev. 2022 Jan:180:114046. doi: 10.1016/j.addr.2021.114046. Epub 2021 Nov 9.

Authors

Jipeng Jiang¹, Jie Mei², Shaoqiong Yi³, Changjiang Feng³, Yongfu Ma³, Yang Liu⁴, Ying Liu⁵, Chunying Chen⁶

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, PR China; Postgraduate School, Medical School of Chinese PLA, Beijing 100853, PR China; Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China.
² CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, PR China; University of Chinese Academy of Science, Beijing 100049, PR China.
³ Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China.
⁴ Postgraduate School, Medical School of Chinese PLA, Beijing 100853, PR China; Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China. Electronic address: sunny301x@sina.com.
⁵ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, PR China; GBA National Institute for Nanotechnology Innovation, Guangzhou, Guangdong 510700, PR China. Electronic address: liuy@nanoctr.cn.
⁶ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, PR China; University of Chinese Academy of Science, Beijing 100049, PR China; GBA National Institute for Nanotechnology Innovation, Guangzhou, Guangdong 510700, PR China. Electronic address: chenchy@nanoctr.cn.

PMID: 34767863
DOI: 10.1016/j.addr.2021.114046

Abstract

The occurrence and development of tumors depend on the tumor microenvironment (TME), which is made of various immune cells, activated fibroblasts, basement membrane, capillaries, and extracellular matrix. Tumor associated macrophages (TAMs) and microbes are important components in TME. Tumor cells can recruit and educate TAMs and microbes, and the hijacked TAMs and microbes can promote the progression of tumor reciprocally. Tumor vaccine delivery remodeling TME by targeting TAM and microbes can not only enhance the specificity and immunogenicity of antigens, but also contribute to the regulation of TME. Tumor vaccine design benefits from nanotechnology which is a suitable platform for antigen and adjuvant delivery to catalyze new candidate vaccines applying to clinical therapy at unparalleled speed. In view of the characteristics and mechanisms of TME development, vaccine delivery targeting and breaking the malignant interactions among tumor cells, TAMs, and microbes may serve as a novel strategy for tumor therapy.

Keywords: Macrophage; Microbiota; Tumor microenvironment; Tumor vaccine; Vaccine delivery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cancer Vaccines / administration & dosage*
Cancer Vaccines / immunology
Disease Progression
Drug Delivery Systems
Humans
Nanotechnology
Neoplasms / immunology
Neoplasms / microbiology
Neoplasms / therapy*
Tumor Microenvironment / immunology
Tumor-Associated Macrophages / metabolism*

Substances

Cancer Vaccines