The biological role of metabolic reprogramming in pancreatic cancer

Tatsunori Suzuki; Motoyuki Otsuka; Takahiro Seimiya; Takuma Iwata; Takahiro Kishikawa; Kazuhiko Koike

doi:10.1002/mco2.37

The biological role of metabolic reprogramming in pancreatic cancer

MedComm (2020). 2020 Nov 5;1(3):302-310. doi: 10.1002/mco2.37. eCollection 2020 Dec.

Authors

Tatsunori Suzuki¹, Motoyuki Otsuka¹, Takahiro Seimiya¹, Takuma Iwata¹, Takahiro Kishikawa¹, Kazuhiko Koike¹

Affiliation

¹ Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.

PMID: 34766124
PMCID: PMC8491225
DOI: 10.1002/mco2.37

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired metabolism are currently underway. In this review, we summarize the vital role of metabolic reprogramming in the development of PDAC and the future of novel therapeutic applications.

Keywords: autophagy; macropinocytosis; metabolism; pancreatic cancer; tumor microenvironment.

Publication types

Review