Silver nanoparticle based multifunctional approach for combating COVID-19

Prince Allawadhi; Vishakha Singh; Amit Khurana; Isha Khurana; Sachin Allwadhi; Pawan Kumar; Anil Kumar Banothu; Sunitha Thalugula; Percy Jasmine Barani; Ramavath Redya Naik; Kala Kumar Bharani

doi:10.1016/j.sintl.2021.100101

Silver nanoparticle based multifunctional approach for combating COVID-19

Sens Int. 2021:2:100101. doi: 10.1016/j.sintl.2021.100101. Epub 2021 Jun 2.

Authors

Prince Allawadhi¹, Vishakha Singh², Amit Khurana^{3

4

5}, Isha Khurana⁶, Sachin Allwadhi⁷, Pawan Kumar⁸, Anil Kumar Banothu^{4

9}, Sunitha Thalugula¹⁰, Percy Jasmine Barani¹¹, Ramavath Redya Naik¹², Kala Kumar Bharani^{5

9}

Affiliations

¹ Department of Pharmacy, Vaish Institute of Pharmaceutical Education and Research (VIPER), Pandit Bhagwat Dayal Sharma University of Health Sciences (Pt. B. D. S. UHS), Rohtak - 124001, Haryana, India.
² Department of Biotechnology, Indian Institute of Technology (IIT) Roorkee, Roorkee - 247667, Uttarakhand, India.
³ Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi - 110016, India.
⁴ Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Rajendranagar, Hyderabad - 500030, PVNRTVU, Telangana, India.
⁵ Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Warangal - 506166, PVNRTVU, Telangana, India.
⁶ Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh - 160014, India.
⁷ Department of Computer Science and Engineering, University Institute of Engineering and Technology (UIET), Maharshi Dayanand University (MDU), Rohtak - 124001, Haryana, India.
⁸ Department of Radiation Oncology, Regional Cancer Centre, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (Pt. B. D. S. PGIMS), Rohtak - 124001, Haryana, India.
⁹ Department of Aquatic Animal Health Management, College of Fishery Science, Pebbair, Wanaparthy - 509104, PVNRTVU, Telangana, India.
¹⁰ Department of Pharmacology, University College of Pharmaceutical Sciences (UCPS), Kakatiya University, Warangal - 506009, Telangana, India.
¹¹ Department of Chemistry, Wesley Degree College for Women, Osmania University, Secunderabad - 500025, Telangana, India.
¹² Zaney Pharma Innovations, Tarnaka, Hyderabad - 500007, Telangana, India.

Abstract

COVID-19 is a highly contagious and widespread disease that has strained the global healthcare system to the hilt. Silver nanoparticles (AgNPs) are well known for their potent antimicrobial, antiviral, immunomodulatory and biosensing properties. AgNPs have been found to be potential antiviral agent that act against many deadly viruses and is presumed to be effective against COVID-19. AgNPs can generate free radicals and reactive oxygen species (ROS) leading to apoptosis mediated cell death thereby inhibiting viral infection. The shape and size of AgNPs play an important role in its biomedical applications as alterations may result in variable biological interaction and activity. Herein, we propose that AgNPs can be utilized for effective management of the ongoing COVID-19 pandemic by highlighting the current status of AgNPs in the fight against COVID-19.

Keywords: Antimicrobial; Antiviral activity; COVID-19; Cytokine storm; Silver nanoparticles.