Hydroxychloroquine induces matrix metalloproteinase 1 expression and apoptosis in neurofibromatosis type 1 Schwann cells

J Dermatol Sci. 2021 Nov;104(2):142-145. doi: 10.1016/j.jdermsci.2021.09.009. Epub 2021 Oct 1.

Authors

Ayako Yumine¹, Gaku Tsuji²

Affiliations

¹ Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
² Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan. Electronic address: gakku@dermatol.med.kyushu-u.ac.jp.

PMID: 34763989
DOI: 10.1016/j.jdermsci.2021.09.009

No abstract available

Publication types

Letter

MeSH terms

Antimalarials / pharmacology*
Apoptosis / drug effects
Benzamides / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Collagen Type I, alpha 1 Chain / genetics
Dose-Response Relationship, Drug
Gene Expression / drug effects*
Humans
Hydroxychloroquine / pharmacology*
Matrix Metalloproteinase 1 / genetics*
Matrix Metalloproteinase 1 / metabolism
Neurofibromatosis 1 / genetics*
Neurofibromatosis 1 / metabolism
Protein Kinase Inhibitors / pharmacology
Schwann Cells / metabolism
Skin Neoplasms / genetics*
Skin Neoplasms / metabolism

Substances

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide
Antimalarials
Benzamides
COL1A1 protein, human
Collagen Type I, alpha 1 Chain
Protein Kinase Inhibitors
Hydroxychloroquine
MMP1 protein, human
Matrix Metalloproteinase 1