Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats

Shubhra Pande; Rajeev Ranjan; Maria Ryazanova; Anton N Shuvaev; Alla B Salmina; Valentina A Kratasyuk

doi:10.1016/j.foodchem.2021.131507

Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats

Food Chem. 2022 Mar 30;373(Pt B):131507. doi: 10.1016/j.foodchem.2021.131507. Epub 2021 Nov 1.

Authors

Shubhra Pande¹, Rajeev Ranjan², Maria Ryazanova², Anton N Shuvaev³, Alla B Salmina⁴, Valentina A Kratasyuk⁵

Affiliations

¹ Laboratory of Bioluminescent Biotechnologies, Department of Biophysics, Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Svobodny Prospect 79, Krasnoyarsk 660041, Russia; Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, P. Zheleznyaka 1, Krasnoyarsk 660022, Russia. Electronic address: drshubhrapande@gmail.com.
² Laboratory of Bioluminescent Biotechnologies, Department of Biophysics, Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Svobodny Prospect 79, Krasnoyarsk 660041, Russia.
³ Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, P. Zheleznyaka 1, Krasnoyarsk 660022, Russia.
⁴ Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, P. Zheleznyaka 1, Krasnoyarsk 660022, Russia; Laboratory of Experimental Brain Cytology, Research Center of Neurology, Moscow, Russia.
⁵ Laboratory of Bioluminescent Biotechnologies, Department of Biophysics, Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Svobodny Prospect 79, Krasnoyarsk 660041, Russia; Institute of Biophysics SB RAS, Federal Research Center 'Krasnoyarsk Science Center SB RAS', Akademgorodok 50/50, Krasnoyarsk 660036, Russia.

PMID: 34763933
DOI: 10.1016/j.foodchem.2021.131507

Abstract

Present study investigated effect of dietary buckwheat in alleviating bisphenol A (BPA) mediated oxidative stress, concomitant sirtuin1 levels in serum, stomach, and liver of rats. Experimental group A and B ingested standard diet, C and D consumed buckwheat (30%); group A and C drank normal water, B and C had BPA contamination (10 mg L^-1). Sirtuin1 mean B/A ratio nearing unity in all tissues reveals inertness of BPA towards sirtuin1. Dietary buckwheat improved sirtuin1 levels both in normal (mean C/A ratio of serum, 1.65; liver, 1.24; stomach, 1.78) and BPA fed state (mean D/B ratio of serum, 1.9; liver, 1.26; stomach, 1.75). Buckwheat augmented antioxidant status in BPA fed rats as seen in mean D/B ratio of serum (catalase, 2.4; glutathione reductase (GR), 1.33; Thiols, 1.2), liver (catalase, 2; GR, 2.5; Thiols, 1.36) and stomach (catalase, 1.31; GR, 1.5; Thiols, 1.33). Therefore, buckwheat counters BPA-led oxidative stress and modulates sirtuin1.

Keywords: Bisphenol A; Buckwheat; Dietary intervention; Male Wistar rats; Oxidative stress; Sirtuin1.

MeSH terms

Animals
Antioxidants* / metabolism
Benzhydryl Compounds / metabolism
Catalase / metabolism
Diet
Fagopyrum* / metabolism
Liver / metabolism
Oxidative Stress
Phenols
Rats
Sirtuin 1 / genetics
Sirtuin 1 / metabolism

Substances

Antioxidants
Benzhydryl Compounds
Phenols
Catalase
Sirtuin 1
bisphenol A