Potential inhibitors and plant based technology: An alternative approach to treat corona virus

Bioorg Chem. 2021 Dec:117:105460. doi: 10.1016/j.bioorg.2021.105460. Epub 2021 Nov 1.

Abstract

The current pneumonia outbreak, which began in early December 2019 near Wuhan City, Hubei Province, China, is caused by a novel corona virus (CoV) known as '2019-nCoV' or '2019 novel corona virus or COVID-19' by the World Health Organization (WHO). Vaccines are available to prevent corona virus contagious infection or to reduce the viral load in body but virus is continuously mutating itself to infect people at severity. In this critical scenario this review provide a compiled study for techniques and tools that can be used to treat corona virus infections and its variants by some modern techniques and natural products such as inhibitors, siRNA technique and plant based approaches. This review focuses on healthy treatment and strategies that can be used effectively to treat the disease globally by reducing the post COVID symptoms.

Keywords: Coronavirus; Inhibitors; Plant Secondary Metabolites; siRNA.

Publication types

  • Review

MeSH terms

  • Angiotensin-Converting Enzyme 2 / antagonists & inhibitors
  • Angiotensin-Converting Enzyme 2 / metabolism
  • Biological Products / chemistry*
  • Biological Products / metabolism
  • Biological Products / therapeutic use
  • COVID-19 / pathology
  • COVID-19 / virology
  • COVID-19 Drug Treatment
  • Coronavirus 3C Proteases / antagonists & inhibitors
  • Coronavirus 3C Proteases / metabolism
  • Humans
  • Plants / chemistry
  • Plants / metabolism
  • RNA, Small Interfering / metabolism
  • RNA, Small Interfering / therapeutic use
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / isolation & purification
  • SARS-CoV-2 / metabolism
  • Spike Glycoprotein, Coronavirus / antagonists & inhibitors*
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / metabolism

Substances

  • Biological Products
  • RNA, Small Interfering
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Angiotensin-Converting Enzyme 2
  • 3C-like proteinase, SARS-CoV-2
  • Coronavirus 3C Proteases