Pulmonary nontuberculous mycobacterial disease in Florida and association with large-scale natural disasters

Shweta Kambali; Elena Quinonez; Arash Sharifi; Abdolrazagh Hashemi Shahraki; Naresh Kumar; Jayaweera Dushyantha; Mehdi Mirsaeidi

doi:10.1186/s12889-021-12115-7

Pulmonary nontuberculous mycobacterial disease in Florida and association with large-scale natural disasters

BMC Public Health. 2021 Nov 10;21(1):2058. doi: 10.1186/s12889-021-12115-7.

Authors

Shweta Kambali¹, Elena Quinonez², Arash Sharifi³, Abdolrazagh Hashemi Shahraki⁴, Naresh Kumar⁵, Jayaweera Dushyantha⁶, Mehdi Mirsaeidi⁷

Affiliations

¹ Division of Pulmonary and Critical Care, University of Miami, Miami, Florida, USA.
² School of Medicine, University of Miami, Miami, Florida, USA.
³ Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, Florida, USA.
⁴ Division of Pulmonary, Critical Care and Sleep, College of Medicine-Jacksonville, University of Florida, 653-1 8th St West, Jacksonville, Florida, 32209, USA.
⁵ Department of Public Health Sciences, University of Miami, Miami, Florida, USA.
⁶ Division of Infectious disease, University of Miami, Miami, Florida, USA.
⁷ Division of Pulmonary, Critical Care and Sleep, College of Medicine-Jacksonville, University of Florida, 653-1 8th St West, Jacksonville, Florida, 32209, USA. msm249@med.miami.edu.

Abstract

Background: Little is known about the impact of the ecosystem disruption and its contribution on the non-tuberculosis mycobacteria (NTM) diseases (cases) rate in Florida (FL), a state with a high prevalence of NTM in the United States. We aimed to evaluate the epidemiological distribution of NTM in FL and identify its association with extreme weather events.

Methods: We used OneFlorida Clinical Research Consortium dataset and extracted data on NTM cases using ICD codes 9- CM 031.0 and ICD-10 A31 during 2012-2018. The number of hurricanes during the study period which affected FL were extracted data from the National Hurricane Center (NHC) and the National Oceanic and Atmospheric Administration (NOAA).

Results: Prevalence of NTM gradually increased during the study period. The rate was 2012: 14.3/100,000, 2015; 20.1/100,000 and 2018; 22.6/100,00 except in 2014 where there was an 8% decrease. The incidences were 2012; 6.5/100,00, 2015; 4.9/100,000 and in 2015; 5.4/100,000. Geographical analysis demonstrated a gradual expansion of the NTM cases in Alachua, and Marion Counties throughout the study period. Notably, the 2018 heat map showed higher prevalence of NTM in the northwestern, panhandle region of FL which had been absent in the heat maps for years 2012-2018. High number of the hurricanes was associated with the higher number of the new cases of NTM infection for years 2012, 2016-2018, while the lower number of the hurricanes was associated with the lower number of the new cases of NTM infection for years 2014-2015.

Conclusion: The current study found the prevalence rates of NTM disease in FL rose from 2012 to 2018. A higher prevalence was seen following the hurricanes.

Keywords: Florida; Hurricane; Mycobacteria; NTM; Nontuberculous.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclonic Storms*
Ecosystem
Florida / epidemiology
Humans
Mycobacterium Infections, Nontuberculous* / epidemiology
Nontuberculous Mycobacteria
United States