A new anthraquinone, asperquinone A (1), and four known anthraquinone derivatives 2-5 were isolated from the mangrove endophytic fungus Aspergillus sp. 16-5C. These structures were elucidated by spectroscopic analysis and the absolute configuration of 1 was unambiguously determined by ECD calculation. Compounds 1-5 showed no significant inhibitory effect against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).
Keywords: Aspergillus sp.; Mangrove endophytic fungus; anthraquinone; secondary metabolites.