sLRP1'in up retinol keeps the gut SAAfe

Jasmine Labuda; Oliver J Harrison

doi:10.1016/j.immuni.2021.10.013

sLRP1'in up retinol keeps the gut SAAfe

Immunity. 2021 Nov 9;54(11):2447-2449. doi: 10.1016/j.immuni.2021.10.013.

Authors

Jasmine Labuda¹, Oliver J Harrison²

Affiliations

¹ Center for Fundamental Immunology, Benaroya Research Institute, 1201 9(th) Ave., Seattle, WA 98101, USA.
² Center for Fundamental Immunology, Benaroya Research Institute, 1201 9(th) Ave., Seattle, WA 98101, USA; Department of Immunology, University of Washington, 750 Republican St., Seattle, WA 98108, USA. Electronic address: oharrison@benaroyaresearch.org.

PMID: 34758336
DOI: 10.1016/j.immuni.2021.10.013

Abstract

Retinol is shuttled to myeloid cells for conversion to retinoic acid, but the receptor facilitating uptake of SAA:retinol complexes on myeloid cells is unknown. In a recent issue of Science, Bang et al. (2021) use genetic and biochemical approaches to reveal this critical receptor to be LRP1 and show that this axis is essential for intestinal innate and adaptive immune responses.

Publication types

Comment

MeSH terms

Carrier Proteins
Tretinoin* / metabolism
Vitamin A* / metabolism

Substances

Carrier Proteins
Vitamin A
Tretinoin