Microfluidic-based nanoparticle synthesis and their potential applications

Electrophoresis. 2022 Apr;43(7-8):819-838. doi: 10.1002/elps.202100242. Epub 2021 Nov 26.

Abstract

A lot of substantial innovation in advancement of microfluidic field in recent years to produce nanoparticle reveals a number of distinctive characteristics, for instance, compactness, controllability, fineness in process, and stability along with minimal reaction amount. Recently, a prompt development, as well as realization in the production of nanoparticles in microfluidic environment having dimension of micro to nanometers and constituents extending from metals, semiconductors to polymers, has been made. Microfluidics technology integrates fluid mechanics for the production of nanoparticles having exclusive with homogenous sizes, shapes, and morphology, which are utilized in several bioapplications such as biosciences, drug delivery, and healthcare including food engineering. Nanoparticles are usually well-known for having fine and rough morphology because of their small dimensions including exceptional physical, biological, chemical, and optical properties. Though the orthodox procedures need huge instruments, costly autoclaves, use extra power, extraordinary heat loss, as well as take surplus time for synthesis. Additionally, this is fascinating to systematize, assimilate, in addition, to reduce traditional tools onto one platform to produce micro and nanoparticles. The synthesis of nanoparticles by microfluidics permits fast handling besides better efficacy of method utilizing the smallest components for process. Herein, we will focus on synthesis of nanoparticles by means of microfluidic devices intended for different bioapplications.

Keywords: Biomedical applications; Microfluidics; Microreactor; Nanoparticles; Synthesis.

Publication types

  • Review

MeSH terms

  • Drug Delivery Systems
  • Lab-On-A-Chip Devices
  • Microfluidics* / methods
  • Nanoparticles* / chemistry
  • Polymers / chemistry

Substances

  • Polymers