The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors

Bioorg Med Chem. 2021 Nov 15:50:116476. doi: 10.1016/j.bmc.2021.116476. Epub 2021 Oct 19.

Abstract

Succinate dehydrogenase inhibitors (SDHIs) have become one of the fastest growing classes of new fungicides since entering the market, and have attracted increasing attention as a result of their unique structure, high activity and broad fungicidal spectrum. The mechanism of SDHIs is to inhibit the activity of succinate dehydrogenase, thereby affecting mitochondrial respiration and ultimately killing pathogenic fungi. At present, they have become popular varieties researched and developed by major pesticide companies in the world. In the review, we focused on the mechanism, the history, the representative varieties, structure-activity relationship and resistance of SDHIs. Finally, the potential directions for the development of SDHIs were discussed. It is hoped that this review can strengthen the individuals' understanding of SDHIs and provide some inspiration for the development of new fungicides.

Keywords: Main varieties; Resistance; SDH; SDHIs; Structure–activity relationship.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Fungicides, Industrial / chemical synthesis
  • Fungicides, Industrial / chemistry
  • Fungicides, Industrial / pharmacology*
  • Humans
  • Molecular Structure
  • Structure-Activity Relationship
  • Succinate Dehydrogenase / antagonists & inhibitors*
  • Succinate Dehydrogenase / metabolism

Substances

  • Enzyme Inhibitors
  • Fungicides, Industrial
  • SDHD protein, human
  • Succinate Dehydrogenase