The AlphaFold Database of Protein Structures: A Biologist's Guide

J Mol Biol. 2022 Jan 30;434(2):167336. doi: 10.1016/j.jmb.2021.167336. Epub 2021 Oct 29.

Abstract

AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-dimensional models of the whole human proteome to the scientific community. Here we discuss the advantages, limitations and the still unsolved challenges of the AlphaFold models from the perspective of a biologist, who may not be an expert in structural biology.

Keywords: AlphaFold; human proteome; inter-domain accuracy; three-dimensional model.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Computational Biology
  • Databases, Factual
  • Deep Learning*
  • Humans
  • Models, Molecular
  • Molecular Biology
  • Protein Conformation*
  • Protein Folding*
  • Proteome

Substances

  • Proteome