Bone marrow microenvironment of MPN cells

Abstract

In this chapter, we will discuss the current knowledge concerning the alterations of the cellular components in the bone marrow niche in Myeloproliferative Neoplasms (MPNs), highlighting the central role of the megakaryocytes in MPN progression, and the extracellular matrix components characterizing the fibrotic bone marrow.

Keywords: Bone marrow; Extracellular matrix; Megakaryocytes; Myeloproliferative neoplasms.