Message in a platelet: decoding platelet transcriptomes in myeloproliferative neoplasms

Susan Shapiro; Lauren Murphy; Bethan Psaila

doi:10.1016/j.xcrm.2021.100433

Message in a platelet: decoding platelet transcriptomes in myeloproliferative neoplasms

Cell Rep Med. 2021 Oct 19;2(10):100433. doi: 10.1016/j.xcrm.2021.100433.

Authors

Susan Shapiro^{1

2}, Lauren Murphy², Bethan Psaila^{1

2}

Affiliations

¹ Oxford University Hospitals NHS Foundation Trust, Oxford NIHR Biomedical Research Centre, Oxford, UK.
² MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine and National Institutes for Health Research Biomedical Research Centre, University of Oxford, Oxford, UK.

Abstract

Platelets are anucleate but contain a rich repertoire of mRNAs. In this issue of Cell Reports Medicine, Shen and colleagues¹ present platelet transcriptomes from patients with myeloproliferative neoplasms to study disease mechanisms and generate a predictive algorithm for fibrotic progression.

Publication types

Comment

MeSH terms

Blood Platelets
Humans
Myeloproliferative Disorders* / genetics
Neoplasms*
RNA, Messenger
Transcriptome

Substances

RNA, Messenger

Abstract

Publication types

MeSH terms

Substances

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