Systemic infection following intravesical therapy with BCG

BMJ Case Rep. 2021 Nov 9;14(11):e243641. doi: 10.1136/bcr-2021-243641.

Abstract

Immunotherapy with BCG is an effective and widely used treatment for non-muscle-invasive bladder cancer. BCG sepsis is a rare but life-threatening and frequently not a straightforward complication of this treatment; in cases with a high index of suspicion, anti-bacillary treatment should not wait for laboratory confirmation and be instituted immediately. We report a severe case of BCG sepsis, in which timely diagnosis and initiation of antituberculosis agents enabled a full recovery.

Keywords: TB and other respiratory infections; urological cancer; urology.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravesical
  • BCG Vaccine* / adverse effects
  • Humans
  • Immunotherapy
  • Sepsis*
  • Urinary Bladder Neoplasms* / drug therapy

Substances

  • BCG Vaccine