Classics never get old: neurotransmitters shape human cortical interneuron migration

EMBO J. 2021 Dec 1;40(23):e109935. doi: 10.15252/embj.2021109935. Epub 2021 Nov 9.

Abstract

While key developmental functions of neurotransmitters have been described in rodent neural progenitors, there is a lack of understanding of their roles in the human fetal brain. A new study published in The EMBO Journal demonstrates that human cortical interneurons that are moving in fused brain organoids express a large repertoire of neurotransmitter receptors whose activation fine tunes selective migration strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Movement
  • Humans
  • Interneurons*
  • Neurogenesis*
  • Neurotransmitter Agents
  • Organoids

Substances

  • Neurotransmitter Agents