Nef-specific CD107a+ CD4+ T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion

Trang Thi Thu Hau; Yoshiaki Kanno; Masako Nishizawa; Takushi Nomura; Tetsuro Matano; Hiroyuki Yamamoto

doi:10.1111/jmp.12551

Nef-specific CD107a⁺ CD4⁺ T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion

J Med Primatol. 2022 Feb;51(1):56-61. doi: 10.1111/jmp.12551. Epub 2021 Nov 8.

Authors

Trang Thi Thu Hau^{1

2}, Yoshiaki Kanno^{1

3}, Masako Nishizawa¹, Takushi Nomura¹, Tetsuro Matano^{1

2

3}, Hiroyuki Yamamoto^{1

4}

Affiliations

¹ AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
² Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
³ The Institute of Medical Science/Graduate School of Medicine/Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
⁴ Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

PMID: 34750827
DOI: 10.1111/jmp.12551

Abstract

Acute-phase neutralizing antibody (NAb) passive immunization in simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta) can confer stringent viremia control with T-cell augmentation. In one NAb-infused SIV partial controller, we identify chronic-phase Nef-specific CD107a⁺ CD4⁺ T-cell response maintenance, implicating that NAb infusion modulates long-term T-cell responses even within viremic control.

Keywords: CD107a; CD4+ T cells; SIV; neutralizing antibody; passive immunization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Neutralizing
CD4-Positive T-Lymphocytes
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome*
Simian Immunodeficiency Virus*
T-Lymphocytes

Substances

Antibodies, Neutralizing