Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group

Anne Mea Spanjaart; Per Ljungman; Rafael de La Camara; Gloria Tridello; Valentín Ortiz-Maldonado; Alvaro Urbano-Ispizua; Pere Barba; Mi Kwon; Dolores Caballero; Pierre Sesques; Emmanuel Bachy; Roberta Di Blasi; Catherine Thieblemont; Friso Calkoen; Pim Mutsaers; Johan Maertens; Livia Giannoni; Emma Nicholson; Matthew Collin; Carlos Pinho Vaz; Elisabetta Metafuni; Joaquin Martinez-Lopez; Fiona L Dignan; Josep-Maria Ribera; Arnon Nagler; Frantisek Folber; Robin Sanderson; Adrian Bloor; Fabio Ciceri; Nina Knelange; Francis Ayuk; Nicolaus Kroger; Marie José Kersten; Stephan Mielke

doi:10.1038/s41375-021-01466-0

Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group

Leukemia. 2021 Dec;35(12):3585-3588. doi: 10.1038/s41375-021-01466-0. Epub 2021 Nov 8.

Authors

Anne Mea Spanjaart^#¹, Per Ljungman^#^{2

3}, Rafael de La Camara⁴, Gloria Tridello⁵, Valentín Ortiz-Maldonado⁶, Alvaro Urbano-Ispizua⁶, Pere Barba⁷, Mi Kwon⁸, Dolores Caballero⁹, Pierre Sesques¹⁰, Emmanuel Bachy¹⁰, Roberta Di Blasi¹¹, Catherine Thieblemont¹¹, Friso Calkoen¹², Pim Mutsaers¹³, Johan Maertens¹⁴, Livia Giannoni¹⁵, Emma Nicholson¹⁶, Matthew Collin¹⁷, Carlos Pinho Vaz¹⁸, Elisabetta Metafuni¹⁹, Joaquin Martinez-Lopez²⁰, Fiona L Dignan²¹, Josep-Maria Ribera²², Arnon Nagler²³, Frantisek Folber²⁴, Robin Sanderson²⁵, Adrian Bloor²⁶, Fabio Ciceri²⁷, Nina Knelange²⁸, Francis Ayuk²⁹, Nicolaus Kroger²⁹, Marie José Kersten¹, Stephan Mielke^{30

31

32}

Affiliations

¹ Department of Hematology, Amsterdam University Medical Centers, Cancer Center Amsterdam and LYMMCARE, Amsterdam, The Netherlands.
² Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital Huddinge and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.
³ Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
⁴ Department of Hematology, Hospital Universitario de La Princesa, Madrid, Spain.
⁵ Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
⁶ Department of Hematology, Hospital Clínic, Barcelona, Spain.
⁷ Department of Hematology, Vall d'Hebron University Hospital, Vall d'Hebron, Barcelona, Spain.
⁸ Department of Hematology, Institute of Health Research Gregorio Marañon, Hospital G. Universitario Gregorio Marañon, Madrid, Spain.
⁹ Department of Hematology, Hospital Universitario de Salamanca, IBSAL, Salamanca, Spain.
¹⁰ Department of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Lyon, Pierre-Bénite, France.
¹¹ Department of Hematology, Assistance Publique Hôpitaux de Paris-Hopital Saint-Louis, Paris, France.
¹² Department of Stem cell Transplantation,Princess Maxima Centre for Paediatric Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.
¹³ Department of Hematology, Erasmus MC Cancer Center, Rotterdam, The Netherlands.
¹⁴ Deptartment of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.
¹⁵ Ematologia e Centro Trapianti, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
¹⁶ Department of Haematology, The Royal Marsden Hospital, London, UK.
¹⁷ Adult HSCT Unit, Northern Centre for Bone Marrow Transplantation, Newcastle Tyne, UK.
¹⁸ BMT Unit, Inst. Português de Oncologia do Porto, Porto, Portugal.
¹⁹ Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
²⁰ Department of Hematology, Hospital Univ. 12 de Octubre, CNIO, Complutense University, Madrid, Spain.
²¹ Clinical Haematology Department, Manchester Royal Infirmary, Manchester, UK.
²² Clinical Hematology Department, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Barcelona, Spain.
²³ Chaim Sheba Medical Center, Tel Aviv University, Tel HaShomer, Tel Aviv-Yafo, Israel.
²⁴ Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czechia.
²⁵ Department of Haematological Medicine, Kings College Hospital, London, UK.
²⁶ Adult Leukaemia and Bone Marrow Transplant Unit, Christie NHS Trust Hospital, University of Manchester, Manchester, UK.
²⁷ Hematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
²⁸ Dept. of Medical Statistics & Bioinformatics, EBMT Data Office, Leiden, The Netherlands.
²⁹ Department of Stem Cell Transplantation, University Hospital Eppendorf, Hamburg, Germany.
³⁰ Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital Huddinge and Karolinska Comprehensive Cancer Center, Stockholm, Sweden. stephan.mielke@ki.se.
³¹ Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. stephan.mielke@ki.se.
³² Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. stephan.mielke@ki.se.

^# Contributed equally.

No abstract available

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 / complications*
Europe
Humans
Immunotherapy, Adoptive
Leukemia, B-Cell / complications*
Leukemia, B-Cell / mortality*
Leukemia, B-Cell / therapy
Lymphoma, B-Cell / complications*
Lymphoma, B-Cell / mortality*
Lymphoma, B-Cell / therapy
Prognosis
Treatment Outcome