Long non-coding RNAs are involved in alternative splicing and promote cancer progression

Jiawei Ouyang; Yu Zhong; Yijie Zhang; Liting Yang; Pan Wu; Xiangchan Hou; Fang Xiong; Xiayu Li; Shanshan Zhang; Zhaojian Gong; Yi He; Yanyan Tang; Wenling Zhang; Bo Xiang; Ming Zhou; Jian Ma; Yong Li; Guiyuan Li; Zhaoyang Zeng; Can Guo; Wei Xiong

doi:10.1038/s41416-021-01600-w

Long non-coding RNAs are involved in alternative splicing and promote cancer progression

Br J Cancer. 2022 May;126(8):1113-1124. doi: 10.1038/s41416-021-01600-w. Epub 2021 Nov 8.

Authors

Jiawei Ouyang^#^{1

2

3}, Yu Zhong^#^{1

2

3}, Yijie Zhang^{1

2}, Liting Yang⁴, Pan Wu², Xiangchan Hou², Fang Xiong⁴, Xiayu Li³, Shanshan Zhang⁴, Zhaojian Gong⁵, Yi He¹, Yanyan Tang¹, Wenling Zhang³, Bo Xiang^{1

2}, Ming Zhou^{1

2}, Jian Ma^{1

2}, Yong Li⁶, Guiyuan Li^{1

2}, Zhaoyang Zeng^{1

2}, Can Guo^{7

8}, Wei Xiong^{9

10

11}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
² Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁵ Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁶ Department of Medicine, Comprehensive Cancer Center Baylor College of Medicine, Houston, TX, USA.
⁷ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. guocde@csu.edu.cn.
⁸ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. guocde@csu.edu.cn.
⁹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
¹⁰ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
¹¹ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.

^# Contributed equally.

Abstract

Alternative splicing (AS) is a key process in which precursor RNAs produce different mature RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared with coding RNA, studies on the functions of long non-coding RNAs (lncRNAs) are far from enough. In fact, lncRNA is an important participant and regulator in the process of AS. On the one hand, lncRNAs regulate cancer progression as AS products of precursor messenger RNA (mRNA), but on the other hand, precursor lncRNA generates cancer-related abnormal splicing variants through AS. In addition, lncRNAs directly or indirectly regulate the AS events of downstream target genes, thus affecting the occurrence and development of cancer. Here, we reviewed how lncRNAs regulate AS and influence oncogenesis in different ways.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alternative Splicing / genetics
Cell Transformation, Neoplastic
Humans
Neoplasms* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
RNA, Messenger

Substances

RNA, Long Noncoding
RNA, Messenger