Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease

Marshall W Hogarth; Prech Uapinyoying; Davi A G Mázala; Jyoti K Jaiswal

doi:10.1016/j.molmed.2021.10.003

Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease

Trends Mol Med. 2022 Jan;28(1):8-11. doi: 10.1016/j.molmed.2021.10.003. Epub 2021 Nov 5.

Authors

Marshall W Hogarth¹, Prech Uapinyoying², Davi A G Mázala³, Jyoti K Jaiswal⁴

Affiliations

¹ Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA. Electronic address: mhogarth@cnmc.org.
² Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA; Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
³ Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA; Department of Kinesiology, College of Health Professions, Towson University, Maryland, USA.
⁴ Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA; Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: jkjaiswal@cnmc.org.

PMID: 34750068
DOI: 10.1016/j.molmed.2021.10.003

Abstract

Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.

Keywords: adipogenesis; fibrosis; injury; muscular dystrophy; osteogenesis; stromal cells.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adipogenesis*
Adult
Cell Differentiation
Humans
Mesenchymal Stem Cells*
Muscle Development
Muscle, Skeletal

Grants and funding

K01 AR077686/AR/NIAMS NIH HHS/United States