Test-retest reliability of duration-related and frequency-related mismatch negativity

Jingyi Wang; Tingting Chen; Xiong Jiao; Kai Liu; Shanbao Tong; Junfeng Sun

doi:10.1016/j.neucli.2021.10.004

Test-retest reliability of duration-related and frequency-related mismatch negativity

Neurophysiol Clin. 2021 Dec;51(6):541-548. doi: 10.1016/j.neucli.2021.10.004. Epub 2021 Nov 5.

Authors

Jingyi Wang¹, Tingting Chen¹, Xiong Jiao², Kai Liu¹, Shanbao Tong³, Junfeng Sun⁴

Affiliations

¹ Shanghai Med-X Engineering Research Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
² Shanghai Med-X Engineering Research Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Shanghai Med-X Engineering Research Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China.
⁴ Shanghai Med-X Engineering Research Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. Electronic address: jfsun@sjtu.edu.cn.

PMID: 34750039
DOI: 10.1016/j.neucli.2021.10.004

Abstract

Objectives: -Mismatch negativity (MMN) has been demonstrated as a potential biomarker for pre-attentive processing and prognosis in patients with psychosis. However, previous studies mainly evaluated the reliability of MMN across only two repeated sessions, which is inadequate to draw a convincing conclusion. The current study aimed to assess multi-session test-retest reliability in duration-related MMN (dMMN) and frequency-related MMN (fMMN).

Methods: -We recorded four repeated sessions of electroencephalography (EEG) from 16 healthy participants in an oddball task. MMNs were extracted and their reliability was evaluated by intra-class coefficient (ICC). We also analyzed the correlation between fMMN and dMMN.

Results: -Both dMMN and fMMN amplitudes exhibited good test-retest reliability, and fMMN had better reliability (average ICC = 0.7279) than dMMN (average ICC = 0.6974). Moreover, dMMN and fMMN showed more than moderate linear correlation in amplitudes (r = 0.598, CI: [0.100, 0.857]).

Conclusion: -Both the duration- and frequency-related MMN amplitudes were highly reliable across four-session experiments. These results provide further evidence for the potential utility of MMNs as biomarkers in research into brain function, and prognosis in psychotic illness.

Keywords: Duration-related MMN; Frequency-related MMN; Intraclass coefficient (ICC); Mismatch negativity (MMN); Test-retest reliability.

MeSH terms

Acoustic Stimulation
Attention
Electroencephalography
Evoked Potentials, Auditory
Healthy Volunteers
Humans
Psychotic Disorders* / diagnosis
Reproducibility of Results