New Key Players in Irritant Contact Dermatitis: Residential Skin Cells and Neutrophils Drive Inflammation

Antti Lauerma; Paulina Werner; Lukas Wisgrill; Nanna Fyhrquist

doi:10.1016/j.jid.2021.09.002

New Key Players in Irritant Contact Dermatitis: Residential Skin Cells and Neutrophils Drive Inflammation

J Invest Dermatol. 2022 Mar;142(3 Pt A):509-512. doi: 10.1016/j.jid.2021.09.002. Epub 2021 Nov 5.

Authors

Antti Lauerma¹, Paulina Werner², Lukas Wisgrill³, Nanna Fyhrquist²

Affiliations

¹ Department of Dermatology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. Electronic address: antti.lauerma@hus.fi.
² Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescence Medicine, Medical University of Vienna, Vienna, Austria.

PMID: 34749986
DOI: 10.1016/j.jid.2021.09.002

Abstract

The chemokine CCL2 is a potential biomarker for progression of inflammatory skin disease. In a new article of the Journal of Investigative Dermatology, Shibuya et al. (2021) use murine experimental models to show that CCL2‒CCR2‒dependent IL-1β secretion by local skin cells and skin-infiltrating neutrophils are key drivers of skin irritation.

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MeSH terms

Animals
Dermatitis, Irritant*
Inflammation
Irritants / pharmacology
Mice
Neutrophils* / drug effects
Receptors, CCR2
Skin / drug effects
Surface-Active Agents

Substances

Ccr2 protein, mouse
Irritants
Receptors, CCR2
Surface-Active Agents