Tanshinone IIA: Pharmacology, Total Synthesis, and Progress in Structure-modifications

Abstract

Tanshinone IIA, a major bioactive constituent of Danshen, a Chinese herbal medicine, has gained extensive exploration owing to its unique structural features and multiple promising biological activities. This review focuses on the pharmacology, total synthesis, and structural modifications of tanshinone IIA. We hope this review will contribute to a better understanding of the progress in the field and provide constructive suggestions for further study of tanshinone IIA.

Keywords: Chinese medicine; Salvia miltiorrhiza; Tanshinone IIA; pharmacology; structure-modifications; synthesis.