5-Substituted 1,2,4-Triazole-3-Carboxylates and 5-Substituted Ribavirin Analogs Synthesis

Abstract

Ribavirin analogs substituted at position 5 of the heterocyclic base are interesting for their biological activity. This protocol describes a synthetic route to several such ribavirin analogs with a wide range of substituents.© 2021 Wiley Periodicals LLC. Basic Protocol 1: Synthesis and purification of 5-substituted ethyl 1,2,4-triazole-3-carboxylates - synthetic precursors of nucleobases Basic Protocol 2: Synthesis and purification of protected 1,2,4-triazole nucleoside analogs Basic Protocol 3: Synthesis and purification of 5-substituted ribavirin analogs.

Keywords: 5-substituted ethyl 1,2,4-triazole-3-carboxylates; nucleoside analogs; ribavirin analogs.