Anterior chamber infiltration of CAR T-cells

Elad Jacoby; Ofira Zloto; Vicktoria Vishnevskia Dai

doi:10.1016/j.ajoc.2021.101223

Anterior chamber infiltration of CAR T-cells

Am J Ophthalmol Case Rep. 2021 Oct 22:24:101223. doi: 10.1016/j.ajoc.2021.101223. eCollection 2021 Dec.

Authors

Elad Jacoby^{1

2}, Ofira Zloto^{2

3}, Vicktoria Vishnevskia Dai^{2

3}

Affiliations

¹ Division of Pediatric Hematology, Oncology and BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
² Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
³ Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.

Abstract

A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians. This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second - given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis.

Keywords: CAR T cells; Leukemia.