A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health

Sneha Singh; Anootpal Gogoi; Ashish Kumar; Eesha; Rinku Jagnade; Gaurav Jain; Sanjay Rastogi; Sanjay Dutta

doi:10.1016/j.jobcr.2021.09.020

A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health

J Oral Biol Craniofac Res. 2022 Jan-Feb;12(1):22-26. doi: 10.1016/j.jobcr.2021.09.020. Epub 2021 Oct 5.

Authors

Sneha Singh¹, Anootpal Gogoi², Ashish Kumar³, Eesha⁴, Rinku Jagnade⁵, Gaurav Jain⁶, Sanjay Rastogi⁷, Sanjay Dutta⁸

Affiliations

¹ Dept. of Periodontology, Mithila Minority Dental College and Hospital, India.
² Dept. of Periodontology, Regional Dental College, Guwahati, Assam, India.
³ Dept. of Public Health Dentistry, Baba Jaswant Singh Dental College & Hospital, Ludhiana, India.
⁴ Dept. of Oral Pathology, Regional Dental College, Guwahati, Assam, India.
⁵ Dept. of Periodontology, Index Institute of Dental Sciences and Research Center, Indore, MP, India.
⁶ Dept. of Conservative Dentistry and Endodontics, Saraswati Dental College, Lucknow, Uttar Pradesh, India.
⁷ Dept. of Oral and Maxillofacial Surgery, Regional Dental College, Bhangagarh Guwahati, Assam, 781032, India.
⁸ Dept. of Oral Medicine and Radiology, Regional Dental College, Bhangagarh Guwahati, Assam, 781032, India.

Abstract

Background/purpose: This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling and root planing in patients with chronic gingivitis.

Materials and methods: The participants were randomly assigned to one of two treatment groups: the experimental group (n = 50), which received 10 mg of Lycopene a day for two weeks, or the control group (n = 50) received a placebo for two weeks. For each category, quadrant distribution was randomized, with two quadrants receiving oral prophylaxis (OP) and two quadrants receiving no care (non-OP). At baseline, 1st, and 2nd weeks, the sulcus bleeding index, plaque index, gingival index, and salivary uric acid level were measured.

Results: All clinical criteria, including SBI, PI, GI, and salivary uric acid levels, showed a statistically significant decline in all patient types. Both clinical parameters were significantly reduced (p < 0.001) in the OP-lycopene group relative to the non-OP-placebo group and non-OP lycopene group (p < 0.05). The PI value in the OP-lycopene group was statistically significantly lower (p < 0.001) than in the non-OP-placebo group; there was no statistically significant difference in the other groups. Salivary uric acid levels in the OP- and non-OP- lycopene groups were significantly lower (p < 0.001) than in the non-OP-placebo population.

Conclusion: Based on the findings of this study, Lycopene seems to have a bright future as a treatment option for plaque-induced generalized chronic marginal gingivitis. More research with a broad sample size and multicentre trials is required.

Clinical relevance: The article reveals the positive relationship between Lycopene and gingivitis. The analysis shows that a combination of systemically administered Lycopene with oral prophylaxis can be a valuable tool in treating chronic gingivitis and controlling respiratory oxidative stress.

Keywords: Chronic gingivitis; Lycopene; Oral prophylaxis; Placebo; ROS.