Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry

Yu Nakamichi; Kai-Shih Chiu; Chia-Wei Sun

doi:10.1364/BOE.432297

Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry

Biomed Opt Express. 2021 Sep 2;12(10):5955-5968. doi: 10.1364/BOE.432297. eCollection 2021 Oct 1.

Authors

Yu Nakamichi¹, Kai-Shih Chiu², Chia-Wei Sun²

Affiliations

¹ Department of Mechanical Engineering, Faculty of Engineering, Sanyo-Onoda City University, 1-1-1, Daigaku-dori, Sanyo-Onoda, Yamaguchi, 756-0884, Japan.
² Biomedical Optical Imaging Lab, Department of Photonics, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu, 30010, Taiwan.

Abstract

Split-spectrum amplitude-decorrelation angiography (SSADA) is a noninvasive and three-dimensional angiographic technique with a microscale spatial resolution based on optical coherence tomography. The SSADA signal is known to be correlated with the blood flow velocity and the quantitative velocimetry with SSADA has been expected; however, the signal properties of SSADA are not completely understood due to lack of comprehensive investigations of parameters related to SSADA signals. In this study, phantom experiments were performed to comprehensively investigate the relation of SSADA signals with flow velocities, time separations, particle concentrations, signal-to-noise ratios, beam spot sizes, and viscosities, and revealed that SSADA signals reflect the spatial commonality within a coherence volume between adjacent A-scans.