The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A

Weiwei Sun; Bin Zhang; Qingli Bie; Na Ma; Na Liu; Zewei Shao

doi:10.1155/2021/8874360

The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m⁶A

Stem Cells Int. 2021 Oct 28:2021:8874360. doi: 10.1155/2021/8874360. eCollection 2021.

Authors

Weiwei Sun¹, Bin Zhang², Qingli Bie², Na Ma¹, Na Liu¹, Zewei Shao¹

Affiliations

¹ Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, China.
² Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

Abstract

The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases.

Publication types

Review