Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus

Nelam Sajjad; Song Wang; Ping Liu; Ji-Long Chen; Xiaojuan Chi; Shasha Liu; Shujie Ma

doi:10.3389/fmicb.2021.742984

Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus

Front Microbiol. 2021 Oct 22:12:742984. doi: 10.3389/fmicb.2021.742984. eCollection 2021.

Authors

Nelam Sajjad¹, Song Wang¹, Ping Liu¹, Ji-Long Chen^{1

2}, Xiaojuan Chi¹, Shasha Liu¹, Shujie Ma¹

Affiliations

¹ Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
² CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Abstract

Non-coding RNAs (ncRNAs) are extensively expressed in various cells and tissues, and studies have shown that ncRNAs play significant roles in cell regulation. However, in the past few decades, the knowledge of ncRNAs has been increased dramatically due to their transcriptional ability and multiple regulatory functions. Typically, regulatory ncRNAs include long ncRNAs (lncRNAs), miRNAs, piRNAs, Y RNAs, vault RNAs, and circular RNAs (circRNAs), etc. Previous studies have revealed that various ncRNAs are involved in the host responses to virus infection and play critical roles in the regulation of host-virus interactions. In this review, we discuss the conceptual framework and biological regulations of ncRNAs to elucidate their functions in response to viral infection, especially influenza A virus (IAV) infection. In addition, we summarize the ncRNAs that are associated with innate immunity and involvement of interferons and their stimulated genes (ISGs) during IAV infection.

Keywords: infection; influenza A virus; innate immunity; interferons; non-coding RNAs.

Publication types

Review