Lung cancer ranks the first cancer-related morbidity and mortality in China. Tumor metastasis always predicts the poor prognosis for patients. Moreover, lymphatic metastasis is one of the most significant predictors of poor prognosis in patients with non-small cell lung cancer (NSCLC) and lymphangiogenesis represents the bridge that functionally facilitates tumor lymphatic metastasis. In this review, we first discussed the molecular mechanisms of tumor-associated lymphangiogenesis and the interaction between tumor microenvironment and lymphatic endothelial cells, then, summarized the role of non-coding RNA in regulating tumor-associated lymphangiogenesis in recent frontier studies, with the aim to provide some novel insights on NSCLC-related lymphangiogenesis research, diagnosis and treatment. .
【中文题目：淋巴管生成与非小细胞肺癌淋巴转移的机制研究进展】 【中文摘要：肺癌在我国的发病率和死亡率均排名第一，肿瘤发生转移往往预示患者预后不良。其中，非小细胞肺癌（non-small cell lung cancer, NSCLC）的淋巴转移是导致患者预后不良的重要因素。淋巴管生成是促进肿瘤淋巴转移的重要环节。本文综述肿瘤相关淋巴管生成的分子机制，探讨肿瘤微环境与淋巴管内皮细胞间的相互作用，并总结了目前关于非编码RNA对于肿瘤相关淋巴管生成调控机制的研究及进展，以期为NSCLC相关淋巴管生成的研究与诊疗提供新的思路。 】 【中文关键词：肺肿瘤；淋巴转移；淋巴管生成；肿瘤微环境；非编码RNA】.
Keywords: Lung neoplasms; Lymphangiogenesis; Lymphatic metastasis; Non-coding RNA; Tumor microenvironment.