Objective: To discuss the ultrasonic manifestations of blind microphthalmia, and to explore the correlation between axis length and complicity of intraocular structure of blind microphthalmia. Methods: Retrospective case series study. The data of ultrasonic imaging and axis length of 162 patients (162 eyes) with blind microphthalmia diagnosed in Tongren Eye Center, Beijing Tongren Hospital from July 2013 to July 2018 were collected. According to the degree of internal structure disorder, all affected eyes were divided into groups of the normal, the abnormal and the indistinguishable. The binocular axial length in these patients were compared. The relationship between the axial length and the age of the patients, and the structural changes of the blind microphthalmia with a basic structure were analyzed. Statistical methods were mainly performed by paired t-test, one-way linear regression analysis and one-way analysis of variance. Results: The disease was unilateral in all the 162 patients. The age ranged from 1 month to 58 years old. And 139 cases (85.80%) were under 12 years old. There were 90 males and 72 females. The mean axial length of the affected eyes (162 eyes) was (13.17±3.77) mm, while the mean axial length of the control eyes (162 eyes) was (21.85±2.01) mm. There was significantly statistical difference in the ocular size between them (t=-27.369; P<0.01). There was no significant correlation between the axial length of the affected eye and age in patients with unilateral blind microphthalmia (r=0.027; P>0.05), while there was a significant correlation between the axial length of the control eye and age (r=0.590; P<0.01). The axial length of the groups of the normal (14 eyes), the abnormal (91 eyes) and the indistinguishable (57 eyes) was (17.80±2.19) mm, (14.81±2.92) mm and (10.05±2.46) mm, respectively, and the difference was statistically significant (F=72.800; P<0.01), and there was also significant difference between the two groups (all P<0.01). Ocular ultrasonic imaging showed that 105 eyes (64.81%) had a basic ocular structure, 83 eyes (51.23%) had retinal detachment, 15 eyes (9.26%) had bulbar ossification, and 10 eyes (6.17%) had optic disc abnormality. Conclusions: Blind microphthalmia mostly has a basic ocular structure and is often associated with retinal detachment. The axial length of the affected eye is correlated with the degree of intraocular structural disorder. (Chin J Ophthalmol, 2021, 57: 825-829).
目的： 探讨先天性盲性小眼球的超声影像学表现及其眼轴长度与眼球内组织结构紊乱程度的相关性。 方法： 回顾性系列病例研究。收集2013年6月至2018年6月于首都医科大学附属北京同仁医院确诊为先天性盲性小眼球的162例（162只眼）患者的超声影像资料，根据患眼球内组织结构紊乱程度分为球内结构基本正常、可见球内基本结构但合并组织结构异常改变、球内结构分辨不清3个组。比较患眼与对侧眼及患眼不同结构紊乱程度分组间的眼轴长度，分析眼轴长度与年龄的相关性并总结患眼超声影像表现。统计学方法主要采用配对t检验、单因素线性回归分析及单因素方差分析。 结果： 162例患者均为单眼发病，年龄1个月至58岁，12岁以下139例（85.80%）；男性90例，女性72例；患眼的眼轴长度为（13.17±3.77）mm，对侧眼的眼轴长度为（21.85±2.01）mm，二者差异有统计学意义（t=-27.369；P<0.01）。患眼的眼轴长度与年龄无相关性（r=0.027；P>0.05），对侧眼的眼轴长度与年龄有相关性（r=0.590；P<0.01）。球内结构基本正常组14只眼、可见球内基本结构但合并组织结构异常改变组91只眼、球内结构分辨不清组57只眼，3个组的眼轴长度分别为（17.80±2.19）、（14.81±2.92）、（10.05±2.46）mm，三者间差异有统计学意义（F=72.800，P<0.01），两两比较差异亦均有统计学意义（均P<0.01）。162只眼的超声影像可见眼球基本结构105只眼（64.81%），其中视网膜脱离83只眼（51.23%），球壁骨化15只眼（9.26%），视盘异常10只眼（6.17%）。 结论： 先天性盲性小眼球的超声影像多可见基本眼球结构，最常合并视网膜脱离；患眼眼轴长度与眼内结构紊乱程度有关。（中华眼科杂志，2021，57：825-829）.