Tailoring the physicochemical properties of nanomaterials for immunomodulation

Junjie Deng; Jilong Wang; Jiaqi Shi; Hongjun Li; Mingqin Lu; Zhiyuan Fan; Zhen Gu; Hao Cheng

doi:10.1016/j.addr.2021.114039

Tailoring the physicochemical properties of nanomaterials for immunomodulation

Adv Drug Deliv Rev. 2022 Jan:180:114039. doi: 10.1016/j.addr.2021.114039. Epub 2021 Nov 3.

Authors

Junjie Deng¹, Jilong Wang¹, Jiaqi Shi², Hongjun Li³, Mingqin Lu⁴, Zhiyuan Fan⁵, Zhen Gu⁶, Hao Cheng⁷

Affiliations

¹ Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Joint Centre of Translational Medicine, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; Oujiang Laboratory, Wenzhou, Zhejiang 325000, China.
² College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
³ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Zhejiang Laboratory of Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, China.
⁴ Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
⁵ Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
⁶ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Zhejiang Laboratory of Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, China. Electronic address: guzhen@zju.edu.cn.
⁷ Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA. Electronic address: hcheng@drexel.edu.

PMID: 34742825
DOI: 10.1016/j.addr.2021.114039

Abstract

Immunomodulation is poised to revolutionize the treatment of cancer, autoimmune diseases, and many other inflammation-related disorders. The immune system in these conditions can be either activated or suppressed by nanocarriers loaded with bioactive molecules. Although immunomodulation via these therapeutics has long been recognized, and a broad range of nanocarriers have been designed to accommodate varied usages, less studies have focused on the effects of nanomaterial physicochemical properties on immune responses, especially the immunity altered by nanocarrier materials alone. Conclusions are sometimes seemly inconsistent due to the complexities of nanomaterials and the immune system. An in-depth understanding of the nanocarrier-induced immune responses is essential for clinical applications. In this review, we summarize recent studies of the immune responses influenced by nanomaterial physicochemical properties with an emphasis on the intrinsic features of nanomaterials that modulate the innate and adaptive immunities. We then provide our perspectives on the design of nanomaterials for immunomodulation.

Keywords: Complement; Drug delivery; Immunoengineering; Immunotherapy; Nanomaterials.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Delivery Systems*
Humans
Immunologic Factors / chemistry*
Immunotherapy
Nanoparticles / chemistry*

Substances

Immunologic Factors