Benign Bone-Forming Tumors

Fernanda Amary; Adrienne M Flanagan; Paul O'Donnell

doi:10.1016/j.path.2021.06.002

Benign Bone-Forming Tumors

Surg Pathol Clin. 2021 Dec;14(4):549-565. doi: 10.1016/j.path.2021.06.002. Epub 2021 Oct 7.

Authors

Fernanda Amary¹, Adrienne M Flanagan², Paul O'Donnell³

Affiliations

¹ Histopathology Department, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Greater London HA7 4LP, UK; Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK. Electronic address: Fernanda.amary@nhs.net.
² Histopathology Department, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Greater London HA7 4LP, UK; Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK.
³ Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK; Radiology Department, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Greater London HA7 4LP, UK.

PMID: 34742480
DOI: 10.1016/j.path.2021.06.002

Abstract

Benign bone-forming tumors comprise osteomas, osteoid osteomas, and osteoblastomas. Osteomas affect a wide age range and are usually discovered incidentally. They occur predominantly in the craniofacial skeleton and are classically composed of compact bone. Osteoid osteomas and osteoblastomas are painful lesions occurring in young patients. They are morphologically similar and characterized by FOS gene rearrangement and c-FOS expression at a protein level. Osteoid osteomas are usually smaller than 2 cm in maximum dimension with limited growth potential; osteoblastomas are larger than 2 cm and may be locally aggressive. Histologically both are composed of anastomosing trabeculae of woven bone.

Keywords: Benign; Bone; Bone-forming; Osteoblastoma; Osteoma; Osteoma osteoid.

Publication types

Review

MeSH terms

Bone Neoplasms* / diagnosis
Bone Neoplasms* / genetics
Gene Rearrangement
Humans
Osteoblastoma*
Osteoma, Osteoid*
Soft Tissue Neoplasms*