Preparation and characterization of salicylic acid grafted chitosan electrospun fibers

Abstract

Chitosan (chi) and its modified forms as electrospun nanofibers have potential applications in advanced water treatment and biomedicine. Polyethylene oxide (PEO) is an additive commonly used to facilitate the formation of chitosan electrospun fibers because PEO (Mw ≥ 400 kDa) affords chain entanglement that stabilize the electrospinning jet, leading to enhanced formation of chi-based electrospun fibers. Herein, we report on the preparation of chitosan grafted with salicylic acid and its utility to afford improved electrospun fibers with low molecular weight (LMw) PEO (Mw » 100 kDa). A comparison of the interactions between original and grafted chitosan with PEO reveals that stable supramolecular assemblies are established between grafted chitosan and PEO, which provides support that such supramolecular interactions favor formation of chitosan electrospun fibers. Moreover, a porous chitosan electrospun nanofiber was prepared through physical treatment that reveals notably higher (ca. 4-fold) dye uptake than the pristine (unmodified) chitosan electrospun nanofibers.

Keywords: Characterization; Chitosan; Electrospinning; Nanofibers; Polyethylene oxide; Porosity; Raman spectroscopy; Synthetic modification.