Macrophages in tumor: An inflammatory perspective

Kuntal Kanti Goswami; Anamika Bose; Rathindranath Baral

doi:10.1016/j.clim.2021.108875

Macrophages in tumor: An inflammatory perspective

Clin Immunol. 2021 Nov:232:108875. doi: 10.1016/j.clim.2021.108875. Epub 2021 Nov 2.

Authors

Kuntal Kanti Goswami¹, Anamika Bose², Rathindranath Baral²

Affiliations

¹ Department of Microbiology, Asutosh College, 92, S. P. Mukherjee Road, Kolkata 700026, India. Electronic address: kgoswami1@hotmail.com.
² Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India.

PMID: 34740843
DOI: 10.1016/j.clim.2021.108875

Abstract

Inflammation is a part of carefully co-ordinated healing immune exercise to eliminate injurious stimuli. However, in substantial number of cancer types, it contributes in shaping up of robust tumor microenvironment (TME). Solid TME promotes infiltration of tumor associated macrophages (TAMs) that contributes to cancer promotion. TAMs are functionally heterogeneous and display an extraordinary degree of plasticity, which allow 'Switching' of macrophages into an 'M2', phenotype, linked with immunosuppression, advancement of tumor angiogenesis with metastatic consequences. In contrary to the classical M1 macrophages, these M2 TAMs are high-IL-10, TGF-β secreting-'anti-inflammatory'. In this review, we will discuss the modes of infiltration and switching of TAMs into M2 anti-inflammatory state in the TME to promote immunosuppression and inflammation-driven cancer.

Keywords: Chronic inflammation; Immune response; M1/M2; Macrophage; Tumor microenvironment.

Publication types

Review

MeSH terms

Animals
Humans
Neoplasms / immunology*
Tumor Microenvironment / immunology*
Tumor-Associated Macrophages / immunology*