Avoid shocking your hematopoietic stem cells to keep them young and growing

Maria-Eleni Lalioti; Jasmin Rettkowski; Nina Cabezas-Wallscheid

doi:10.1016/j.stem.2021.10.007

Avoid shocking your hematopoietic stem cells to keep them young and growing

Cell Stem Cell. 2021 Nov 4;28(11):1887-1889. doi: 10.1016/j.stem.2021.10.007.

Authors

Maria-Eleni Lalioti¹, Jasmin Rettkowski¹, Nina Cabezas-Wallscheid²

Affiliations

¹ Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
² Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg, Germany. Electronic address: cabezas@ie-freiburg.mpg.de.

PMID: 34739829
DOI: 10.1016/j.stem.2021.10.007

Abstract

Expanding hematopoietic stem cells (HSCs) ex vivo has historically been a very challenging process. In this issue of Cell Stem Cell, Kruta et al. (2021) identify heat shock factor 1 (Hsf1) as a new target to maintain HSC fitness and protein homeostasis, not only in culture conditions but also upon aging.

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MeSH terms

Hematopoietic Stem Cells*